Table 3.

Platelet parameters in wild type and Svil −/− mice.

Parameter	wild type	Svil −/−	P value*
Platelet number/µL†	1,083,000	969,000	0.67
Mean Forward scatter‡	19.4	23.2	<0.0001
Surface area (µm2)§	4.7 ± 0.1 (N=159)	5.3 ± 0.1 (N=241)	0.0045
Integrin αIIb , MFI ∥ fold change#	1.02		0.89 (n.s.)
GPIbα, MFI ∥ fold change#	1.30		0.40 (n.s.)

^*Calculated by Student’s T-Test (Unless otherwise indicated, N=6 for each genotype)

^†By Hemavet 850FS (Drew Scientific)

^‡By FACScan (Becton Dickinson)

^§Means ± s.e.m. by confocal microscopy of AlexaFluor568-phalloidin stained unactivated

^∥MFI, mean fluorescence intensity ratio of mutant/wild type platelets

^#Flow cytometric comparisons between mice are shown as fold-changes to normalize for day-to-day variation in platelets, antibody fluorescence, binding, and acquisition.