FIGURE 1.

Effects of AnxA1 on leukocyte–endothelial cell interactions. The effects of AnxA1 on leukocyte endothelial cell interactions include: (1) induction of L-selectin-shedding, which may reduce leukocyte rolling. (2) Inhibition of leukocyte adhesion or detachment of already adherent leukocytes, an effect associated with reduced transmigration. (3) A novel cleaved form of AnxA1 has been reported to act on endothelial cells to promote ICAM-1 clustering around transmigrating neutrophils, facilitating transmigration.