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The biogenesis of miRNAs. Mi-RNA genes were transcribed by RNA polymerase II (PloII) into primary miRNA (pri-miRNA). Subsequently processed by Drosha and DGCR8, pri-miRNA forms precursor miRNA (pre-miRNA) and is exported into cytoplasm. In the cytoplasm, pre-miRNA is cleaved by endonuclease enzyme Dicer into mature miRNA. Mature miRNA is loaded into RNA-induced silencing complex (RISC), which results in cleavage or translational repression of target mRNA.
