Skip to main content
. 2012 Nov 20;6(1):80–90.

Table 1.

Bilirubin concentration, bile infarcts, and mRNA expression of collagen-(I)-α1 after BDL

  sham 2 days after BDL 5 days after BDL 14 days after BDL 28 days after BDL
  con DPO con DPO con DPO con DPO
bilirubin (mmol/l) 11 ± 0 247 ± 33 161 ± 17# 343 ± 26 331 ± 30 651 ± 42 554 ± 58 371 ± 44 302 ± 41
bile infarcts (%) 0.1 ± 0.1 5.7 ± 1.3 1.8 ± 0.7# 3.9 ± 1.2 2.3 ± 0.8 6.4 ± 0.8 2.8 ± 1.0# 0.7 ± 0.2 0.5 ± 0.1
mRNA collagen-(I)-α1/GAPDH (rel. density) 0.15 ± 0.03 2.25 ± 0.57 0.33 ± 0.08# 2.65 ± 0.68 1.34 ± 0.36 5.77 ± 1.54 2.02 ± 0.41# 6.09 ± 2.0 3.88 ± 0.66

Plasma bilirubin concentration, histologically assessed bile infarcts and hepatic mRNA expression of collagen-(I)-α1 in sham operated mice (n = 3 – 4) and in animals at 2, 5, 14, and 28 days after BDL with administration of either 10 μg/kg body weight darbepoetin-α (DPO) or physiological saline (con) every third day, beginning 24 h after surgery (n = 6 - 10 per group and time point). Data are given as mean ± s.e.

#

p < 0.05 versus control at the respective time point.

Data are adopted from (Sigal et al. 2010).