Table 1.
Correlation between ALDH1A1 expression and clinicopathologic parameters in NSCLCs
| Low | High | Score (Mean ± SD) | |
|---|---|---|---|
| Age (268) | Chi square test, P = 0.0530 | Student’s t test, P = 0.5598 | |
| Older (181) | 65 (35.9%) | 116 (64.1%) | 42.8 ± 37.6 |
| Younger (87) | 42 (48.3%) | 45 (51.7%) | 39.9 ± 39.9 |
| Gender (268) | Chi square test, P = 0.0794 | Student’s t test, P = 0.4162 | |
| Male (158) | 70 (42.4%) | 88 (57.6%) | 44.1 ± 37.7 |
| Female (110) | 37 (32.7%) | 73 (67.3%) | 39.7 ± 38.7 |
| Smoking History (244) | Chi square test, P = 0.0120 | Student’s t test, P = 0.3440 | |
| Smoker (140) | 68 (48.6%) | 72 (51.4%) | 38.8 ± 49.2 |
| Non-somoker (104) | 34 (33.7%) | 70 (66.3%) | 43.5 ± 37.5 |
| Student’s t test, P = 0.0164 | |||
| Brinkman Index (244) | 692 ± 637 | 494 ± 637 | |
| T factor (268) | Chi square test, P = 0.1640 | ANOVA, not significant in any | |
| T1 (179) | 66 (27.8%) | 113 (72.2%) | 42.9 ± 38.2 |
| T2 (83) | 40 (48.8%) | 43 (51.2%) | 38.2 ± 38.8 |
| T3 (3) | 1 (33.3%) | 2 (66.7%) | 44.4 ± 41.7 |
| T4 (3) | 0 (0.0%) | 3 (100.0%) | 80.6 ± 14.4 |
| N factor (265) | Chi square test, P = 0.2144 | ANOVA, not significant in any | |
| N0 (246) | 97 (39.4%) | 149 (60.6%) | 42.9 ± 38.2 |
| N1 (6) | 2 (33.3%) | 4 (66.7%) | 42.0 ± 35.8 |
| N2 (12) | 6 (50.0%) | 6 (50.0%) | 39.6 ± 40.0 |
| N3 (1) | 1 (100.0%) | 0 (0.0%) | 0.0 ± 0.0 |
| Stage (268) | Chi square test, P = 0.5388 | ANOVA, not significant in any | |
| I (248) | 97 (39.1%) | 151 (60.9%) | 42.2 ± 38.4 |
| II (5) | 2 (40.0%) | 3 (60.0%) | 40.3 ± 41.1 |
| III (14) | 7 (50.0%) | 7 (50.0%) | 39.0 ± 39.4 |
| IV (1) | 1 (100.0%) | 0 (0.0%) | 3.3 ± 0.0 |
| Histology (268) | Chi square test, P = 0.0278 | ||
| ADC (207) | 85 (41.6%) | 122 (58.4%) | ANOVA, *significant in some |
| SQC (43) | 11 (25.5%) | 32 (74.5%) | 39.8 ± 37.9 |
| LCC (18) | 11 (61.1%) | 7 (38.9%) | 58.7 ± 37.4 |
| Grade (268) | Chi square test, P = 0.0180 | ANOVA, #significant in some | |
| WEL (129) | 43 (33.3%) | 86 (66.7%) | 44.4 ± 38.2 |
| MOD (79) | 31 (39.2%) | 48 (60.8%) | 46.1 ± 39.4 |
| POR (60) | 33 (55.0%) | 27 (45.0%) | 30.9 ± 38.2 |
| Growth activity (268) | Chi square test, P = 0.0273 | Student’s t test, P = 0.1989 | |
| High (151) | 69 (45.7%) | 82 (54.3%) | 38.9 ± 38.2 |
| Low (117) | 38 (32.5%) | 79 (67.5%) | 45.0 ± 39.3 |
NSCLCs, non-small cell lung carcinomas; ADC, adenocarcinoma; SQC, squamous cell carcinoma; LCC, large cell carcinoma; WEL, well differentiated; MOD, moderately differentiated; POR, poorly differentiated carcinomas; Older, defined as more than 65 years-old; Growth activity high, defined as tumors with MIB1 labeling index equial to or more than 10%.
*
ADC versus SQC (P = 0.0032); LCC versus SQC (P = 0.0022);
#
WEL versus POR (P = 0.0222); #MOD versus POR (P = 0.0207).