Figure 2.

Measurement of total NOS (tNOS) activity in fragments of nondenervated (ND) and denervated (D) stomachs without lesions and with lesions (ND+MNNG and D+MNNG Groups, respectively). Data are mean ± SE of [¹⁴C]-citrulline generation and expressed as pmol/mg protein/hour (n = 10 fragments per group). iNOS activity was lower than cNOS in all experimental groups (A-C). No differences in NOS activity were detected after myenteric denervation (A, ND and D Groups, * P<0.001). The cNOS activity inside tumors (in; ND+MMG and D+MNNG Groups) was significantly lower than in ND and D stomachs (* P < 0.001) and outside tumors (out; ND+MNNG Group, * P<0.01; D+MNNG Group, * P < 0.001) (B and C).