Fig.
5a. The IFN-γ level in BALF. The level observed was seen to be significantly increased in virus group (II) (P<0.001) on 3rd, 5th and 7th day p.i as compared to control group I (control mice) and group IV (rTGF- β1 treated control mice). Administration of rTGF-β1 down regulated IFN-γ significantly in group III (influenza virus with rTGF- β1) P<0.05 on 3rd day and P<0.001 on 5th and 7th day p.i. 5b. Level of IL-1 β in BALF of infected mice group II increased an average of 16-fold (from 9.33 to 151 pg/ml; P<0.001) on 3rd day p.i. from control group I and maximum increase 22 fold, observed on 5th day p.i. Level of IL-1β remained consistently lower in rTGF-β treated group III and rTGF-β control group IV. 5c. IL-10 level in BALF showing no significant change at day 3 and 5 p.i. and increased significantly (P<0.001) at day 7 p.i. in virus group (II) relative to control group (I) mice. IL-10 concentration in rTGF-β treated group (III) mice increased significantly (P<0.001) from rest of the groups including group IV (rTGF-β control mice) at day 3, 5 and 7 post-infection.