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. 2012 Dec 3;6:287–302. doi: 10.4137/BBI.S10193

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© 2012 the author(s), publisher and licensee Libertas Academica Ltd.

This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.

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Changes in key redox enzymes—multi-resistant strain.

Notes: Shown here are the effects of the combination of the drugs chloroquine and sulfadoxine on key redox enzymes in a multi-resistant plasmodium strain tolerating via its resistance to both chloroquine and the administration of the drug sulfadoxine (yellow bar). The y-axis denotes estimated changes in enzyme activity in percent, the x-axis compares key redox enzymes. For comparison, we show the effects of a triple combination of chloroquine, sulfadoxine, and methylene blue (blue bars) as well as the effects of MB on a non-resistant strain (grayish blue bar). As a baseline, the enzyme activities of a non-resistant strain without any added compounds were taken. Standard deviations (see Fig. 4 legend) after calculating the pathway activities were as follows: wild type: 0.53, wild type and added MB: 0.54, sulfadoxine-pyrimethamine added: 1.75, sulfadoxine-pyrimethamine and MB added: 1.76.