Table 2.

Reagents proposed to act via VDAC (for details, see VDAC as a Pharmacological Target for Compounds Affecting Cell Proliferation or Apoptosis).

Agents	VDAC-mediated cytotoxic	Reference
Avicins	Pro-apoptotic plant stress metabolites, target and close VDAC	Haridas et al. (2007)
Fluoxetine (Prozac)	Anti-depressant induces cell proliferation and cell-line dependent apoptotic modulator. Interacts directly with VDAC, inhibits PTP opening and apoptosis	Nahon et al. (2005)
Cisplatin	Interacts directly with VDAC1 and inhibits PTP opening	Castagna et al. (2004), Yang et al. (2006)
Acrolein	α,β-Unsaturated aldehydes, carbonylates VDAC in Alzheimer’s disease	Mello et al. (2007)
Erastin	Anti-cancer agent that binds directly to VDAC2 to induce cell death	Yagoda et al. (2007)
Endostatin	Small collagen type XVIII fragment, angiogenesis inhibitor. Interacts with VDAC1, inducing PTP opening	Yuan et al. (2008)
Oblimersen	18-mer phosphorothioate anti-sense oligonucleotide. Binds directly to VDAC, blocks channel activity, pro-apoptotic	Tan et al. (2007)
Furanonaphthoquinones	Induce caspase-dependent apoptosis. FNQ-mediated apoptosis is VDAC-dependent	Simamura et al. (2008)
Geldanamycin 17AAG	Binds to VDAC and inhibits cell invasion	Xie et al. (2011)