Table 1.
Association of UDP-glucuronosyltransferase1A1 and thymidylate synthetase genotypes with tumor response
| Genotypes | Tumor response | |
| n (%) | P value1 | |
| UGT1A1*28 | ||
| TA 6/6 | 14 (17.9) | 0.446 |
| TA 6/7, TA 7/7 | 8 (24.2) | |
| UGT1A1*6 | ||
| G/G | 11 (15.7) | 0.217 |
| G/A, A/A | 11 (26.8) | |
| TS promotor | ||
| 3RG/3RG | 3 (17.6) | 0.880 |
| 3RG/3RC, 3RG/2RG | 5 (23.8) | |
| 3RC/3RC, 3RC/2RG, 2RG/2RG | 12 (19.4) | |
1
Fisher’s exact test for all genotypes. Tumor response including complete and partial response, 111 patients were assessable for tumor response. UGT1A1: UDP-glucuronosyltransferase1A1; TS: Thymidylate synthetase.