Table 3.
Association of UDP-glucuronosyltransferase1A1 genotypes with toxicity
| Genotypes | Delayed diarrhea | Neutropenia | ||||||||||
| Grades 2-4 | Grades 3/4 | Grades 3/4 | Grade 4 | |||||||||
| n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | n (%) | P value1 | P value2 | |
| UGT1A1*28 | ||||||||||||
| TA 6/6 | 25 (27.8) | < 0.0005 | < 0.0005 | 14 (15.6) | 0.228 | 0.178 | 23 (25.6) | 0.088 | 0.055 | 7 (7.8) | 0.043 | 0.017 |
| TA 6/7 | 2 (37.5) | 6 (18.8) | 10 (31.3) | 2 (6.3) | ||||||||
| TA 7/7 | 8 (100) | 3 (37.5) | 5 (62.5) | 3 (37.5) | ||||||||
| UGT1A1*6 | ||||||||||||
| G/G | 24 (31.2) | 0.564 | 0.346 | 10 (13) | 0.12 | 0.057 | 23 (29.9) | 1 | 0.748 | 8 (10.4) | 0.857 | 0.473 |
| A/G | 19 (39.6) | 11 (22.9) | 14 (29.2) | 4 (8.3) | ||||||||
| A/A | 2 (40) | 2 (40) | 1 (20) | 0 (0) | ||||||||
1
Fisher’s exact test for all genotype;
2
Exact test of Cochran-Armitage trend test across genotypes. Toxicity grade by National Cancer Institute Common Toxicity Criteria version 3.0. A total of 130 patients were assessable for toxicity. Significant differences were found on grades 2-4 delayed diarrhea and grade 4 neutropenia for UGT1A1*28 genotypes. UGT1A1: UDP-glucuronosyltransferase1A1.