Table 2.
Results of the Approximately Unbiased and Parametric Bootstrap Tests for Comparison of Alternative Phylogenetic Hypotheses
| Hypotheses | ln L | δ ln L | AU Test (P) | PB Test (P) | Rejected |
|---|---|---|---|---|---|
| ML netrin domain | −21377.15 | - | - | - | |
| sFRP-1/2/5 as sister to sFRP-3/4 | −21378.98 | 1.83 | 0.696 | 0.97 | No |
| Netrin-1/2/3/5 as sister to netrin-4 | −21381.31 | 4.16 | 0.574 | 0.81 | No |
| Both netrin and sFRP monophyletic | −21383.31 | 6.16 | 0.443 | 0.62 | No |
| Netrin-4 as sister to Cnidaria/Bilateria netrin-1/2/3/5 | −21390.72 | 13.57 | 0.219 | 0.10 | No |
| Netrin-4 as sister to Deuterostomia netrin-1/2/3/5 | −21411.41 | 34.26 | 0.041 | <0.01 | Yes |
| ML LamininNT-EGF supra-domain | −50081.22 | - | - | - | |
| Netrin-1/2/3/5 as sister to NetrinG | −50157.58 | 76.36 | 0.002 | <0.01 | Yes |
| Netrin-4 as sister to netrin-G | −50186.93 | 105.71 | 0.001 | <0.01 | Yes |
| Netrin-1/2/3/5 as sister to Netrin4 | −50202.58 | 121.36 | 0.0004 | <0.01 | Yes |
| Netrin-4, netrin-G, netrin-4 grouping together | −50271.00 | 189.78 | 0.0002 | <0.01 | Yes |
| ML frizzled-CRD domain | −10872.47 | - | - | - | |
| sFRP1/2/5 as sister to sFRP3/4 | −10876.87 | 4.40 | 0.601 | 0.59 | No |
Note.—ML analyses on complete amino acid datasets under WAG + Γ(8) + I model by PhyML. Constrained analyses performed by RaxML. Log-likelihood values recalculated by PhyML using model, topology, and free parameters from RaxML analyses. See supplementary fig. S11, Supplementary Material online for details about the parametric bootstrap analyses. Bold values indicate significant results at the 5% level.