TABLE 2.

Adverse drug events compared between observational, RCT data in those over 75 and RCT data in patients less than 75 years of age

Side Effect	Pooled Observational Data (Mean age >75)	Seniors Trial (Mean age 79)	Copernicus Trial (Mean Age 63)
Bradycardia	4% (48/1101)	11% (118/1067)	1.5 % (17/1156)
Hypotension	13% (106/829)	8% (82/1067)	1.9% (22/1156)
Worsening HF	5% (44/912)	24% (256/1067)	Not Reported
Weakness/Fatigue	19% (51/222)	7% (72/1067)	Not Reported
Syncope	17% (29/171)	16% (166/1067)	1.6% (19/1156)