TABLE 4.

Predictors of adverse events/tolerability

Study	Krum et al. 2006 Carvedilol	Dinsdale et al. 2005 Spironolactone	Witham et al. 2005 Beta Blockers	Carosella et al. 1996 Digoxin
PREDICTOR
Older Age	Increased ADE	No Effect	No Effect	Increased ADE
Advanced NYHA	Increased ADE	No Effect	Increased ADE	Not Studied
Increased LVEF	Decreased ADE	No Effect	Decreased ADE	Not Studied
Increased DBP	Decreased ADE	Not Studied	Not Studied	Not Studied
Increased SBP	Decreased ADE	Not Studied	Not Studied	Not Studied
Presence of COPD	Increased ADE	Not Studied	No Effect	Not Studied
Intercurrent Illness	Not Studied	Increased ADE	Not studied	Not Studied
Higher Diuretic Dose	Not Studied	Not Studied	No Effect	Not Studied
Multiple Medications	Not Studied	No Effect	Not Studied	Increased ADE
Digoxin Dose Greater than 0.25 mg	Not Studied	Not Studied	Not Studied	Increased ADE
Creatinine > 120 mmol/L	Not Studied	Not Studied	Not Studied	Increased ADE