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. 2012 May 16;4(6):748–759. doi: 10.1093/gbe/evs050

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© The Author(s) 2012. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 1.— — Conservation of a promoter microsatellite. (A) Phylogeny of mammalian species used in our analyses. Branch lengths are measured in average number of substitutions per 4-fold degenerate site. (B) An example of a highly conserved microsatellite (highlighted in yellow) uncovered by the birth–death mixture model. This GT-motif microsatellite is found ∼800 bp upstream of the insulin growth factor 1 (igf1) transcription start site. (C) Generic examples of other patterns of highly conserved loci. The + and − symbols represent present and absent, respectively.