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. Author manuscript; available in PMC: 2012 Dec 6.
Published in final edited form as: Recent Results Cancer Res. 2012;195:25–39. doi: 10.1007/978-3-642-28160-0_3

Fig. 2.

Fig. 2

Scenario 2 envisions that the primary tumor microenvironment (μE) (e.g. hypoxic, collagen dense) can influence the fate of DTCs. The presence of a high (red shade—top) or low (blue shade—bottom) dormancy score signatures encoded in the bulk of the tumor predisposes cells to enter prolonged dormancy (large T′) or after a brief quiescence (small T′) resume proliferation, respectively. PT primary tumor. DTC disseminated tumor cell. HDS high dormancy score. LDS low dormancy score