Figure 1.

Protein expression patterns and the chemoresponses of human breast cancer cell lines. (a) Diphenyltetrazolium bromide (MTT) detection of the chemosensitivities of MCF7, MB231, and MCF15 cells to 5-FU, cisplatin (CDDP), and Gemzar. (b) The basal levels of cell cycle regulatory proteins in 3 cell lines determined by western blot assay. (c) Combination of naphtho [2, 1-a] pyrrolo [3, 4-c] carbazole-5, 7 (6H, 12H)-dione (NPCD) is synergistic with the effects of 5-FU in the MCF7 cell and the attenuate effects of CDDP in MCF15 cells. *P < 0.05