Table 3.
Analysis results for the ARIC study. The Fisher transformation is used for testing ρ, while 50:50 mixture of χ2 distributions is used for testing variances.
| Effect | Estimate | Std. Err | p-value | Estimate | Std. Err | p-value | |
|---|---|---|---|---|---|---|---|
| Full Model | Reduced Model | ||||||
| Longitudinal measures of SBP | |||||||
| Intercept | 1.026 | .062 | < .001 | 1.028 | .061 | < .001 | |
| Age | 0.338 | .044 | < .001 | 0.336 | .044 | < .001 | |
| Male | −0.043 | .053 | .413 | −0.039 | .053 | .461 | |
| Total-cholesterol (mg/dL) | −0.007 | .023 | .766 | −0.007 | .023 | .772 | |
| Hypertension medication | −0.546 | .054 | < .001 | −0.550 | .054 | < .001 | |
| Ever smoker | −0.046 | .054 | .394 | −0.056 | .052 | .288 | |
| Diabetes | 0.088 | .070 | .207 | 0.089 | .070 | .200 | |
| Visit Year | 0.014 | .004 | .001 | 0.013 | .004 | .001 | |
|
|
0.500 | .016 | < .001 | 0.500 | .016 | < .001 | |
| Recurrent CHD event | |||||||
| Age | 0.837 | .264 | .002 | 0.506 | .150 | .001 | |
| Male | 0.871 | .220 | < .001 | 0.795 | .187 | < .001 | |
| Total-cholesterol (mg/dL) | 0.195 | .109 | .073 | 0.184 | .071 | .009 | |
| Hypertension medication | 0.191 | .234 | .414 | 0.108 | .181 | .552 | |
| Ever smoker | 0.862 | .309 | .005 | 0.352 | .182 | .053 | |
| Diabetes | 1.843 | .253 | < .001 | 1.394 | .179 | < .001 | |
| Terminal event | |||||||
| Age | 2.187 | .405 | < .001 | ||||
| Male | 0.611 | .364 | .093 | ||||
| Total-cholesterol (mg/dL) | 0.043 | .231 | .854 | ||||
| Hypertension medication | 0.336 | .393 | .392 | ||||
| Ever smoker | 2.336 | .653 | < .001 | ||||
| Diabetes | 2.671 | .374 | < .001 | ||||
| φ1 | −0.460 | .471 | .329 | ||||
| φ2 | 1.910 | .317 | < .001 | ||||
| Variance components for random effect | |||||||
|
|
0.331 | .024 | < .001 | 0.332 | .024 | < .001 | |
|
|
3.100 | .883 | < .001 | 0.809 | .223 | < .001 | |
| ρ | 0.241 | .086 | .007 | 0.348 | .107 | .003 | |