Table 3.
Effect of aging on experimental ischemia.
| Age |
Aging effect on infarct volume |
|||||
|---|---|---|---|---|---|---|
| Strain/Species | Sex | Young | Aging | Model | Refs | |
| F344 rats | M | 2-3 m | 26-28 m | pMCAO | 24h =; 7d ↑ | [79] |
| Wistar rats | M | 4 m | 20,27m | 100 min tMCAO | 7d ↑ | [80] |
| SD rats | M | 3 m | 6,12,18 m | 20 min tMCAO | 2w ↑ | [81] |
| C57BL6 mice | M | 4 w,4 m | 11,18 m | 60 min tMCAO | 1,3d =; 7d ↑ | [82] |
| Wistar rats | M | 4 m | 22-24 m | pMCAO | 1 m ↓ | [84] |
| C57BL6 mice | M | 2 m | 9,15,24 m | 30 min tMCAO | 2h, 2d, 7d ↓ | [85] |
| C57BL6 mice | M | 4 m | 9,20 m | pMCAO | 24h ↓ | [86] |
| C57BL6 mice | M | 2-3 m | 15-16 m | 90 min tMCAO | 24h ↓ | [72] |
| C57BL6 mice | M | 3 m | 15-16 m | 90 min tMCAO | 24h ↓ | [73] |
| C57BL6 mice | M | 2-3 m | 16-18 m | 91 min tMCAO | 24h,30d ↓ | [87] |
| F344 rats | M | 3 m | 24 m | 60 min tMCAO | 3d = | [88] |
| SD rats | M | 3-4 m | 22-24 m | 60 min tMCAO | 24h,28d = | [89] |
| SD rats | M | 3-4 m | 22-24 m | 60 min tMCAO | 1w = | [90] |
| SD rats | F | 3m | 9,18 m | 2h tMCAO | 24h ↑ | [83] |
| SD rats | F | 3-4 m | 18-20 m | 2h tMCAO | 24h ↑ | [74] |
| SD rats | F | 3-4 m | 18-20 m | 2h tMCAO | 24h ↑ | [75] |
| SD rats | F | 3-4 m | 17-18 m | 2h tMCAO | 24h ↑ | [76] |
| C57BL6 mice | F | 2-3 m | 15-16 m | 90 min tMCAO | 24h ↑ | [72] |
| Wistar rats | Ovx F | 3 m | 15 m | 60 min tMCAO | 7w = | [77] |
| SD rats | Ovx F | 3-4 m | 9-12 m | pMCAO | 24h = | [78] |
M,male; F, female; Ovx, ovariectomy; min, minute; h, hour; d, day; w, week; m, month; p, permanent; t, transient; =, no change; ↑, increase; ↓, decrease.