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. 2012 Sep 15;125(18):4362–4371. doi: 10.1242/jcs.105775

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© 2012. Published by The Company of Biologists Ltd

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Fig. 4. — Cadherin-based traction forces are rigidity and ligand dependent. (A) Root-mean-square (RMS) traction forces (Pa) exerted by MDCK cells on soft (0.6 kPa) and rigid (34 kPa) gels coated with E-cadh.Fc (homophilic) or N-cad.Fc (heterophilic) ligand. (B) Traction force exerted by MDCK cells seeded on E-cad.Fc-coated, rigid (34 kPa) gels, after treatment with blebbistatin or cytochalasin. (C) RMS traction forces exerted by MDA-MB-435 cells on soft (0.6 kPa) and rigid (34 kPa) gels coated with N-cad.Fc (homophilic) or E-cad.Fc (heterophilic) ligand. (D) Control RMS traction force exerted by MDA-MB-435 cells on N-cad.Fc-coated, rigid (34 kPa) gel, after treatment with blebbistatin or cytochalasin D (Cyto D).

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