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. 2012 Dec 1;2(12):1563–1575. doi: 10.1534/g3.112.003780

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Copyright © 2012 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Reduced expression of several DUBs leads to defects on the formation of the margin vein in the adult fly wing. Reduced expression of CG3416 (A), CG18174 (B), CG8445 (C), CG9124 (D), CG9769 (E), or CG32479 (F) in the wing imaginal disc by respective RNAi transgenes driven by the c96-Gal4 driver led to defective wing margin formation, with different degrees of severity. Note that the wing margin defects in panels A and F are stronger than those caused by Notch RNAi (cf. Figure 2D), suggesting that CG3416, which encodes an essential component of the 19S proteasome, and probably CG32479, play additional roles other than those in Notch signaling. Phenotypes shown in panels A (n = 19), B (n = 9), C (n = 15), D (n = 11), E (n = 6), and F (n = 23) are fully penetrant.