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. 2012 Dec 1;2(12):1563–1575. doi: 10.1534/g3.112.003780

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Copyright © 2012 Zhang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution Unported License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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CG32479 positively regulates Notch signaling in the wing imaginal disc. Random clones overexpressing CG32479 RNAi were generated by the FLIPout technique. Knocking down the expression of CG32479 by RNAi in these clones (positively marked by GFP, green) cell-autonomously reduced the expression of Cut (arrows; B) and Wg (arrow; D). Consistently, the production of Notch protein was cell-autonomously downregulated in random clones overexpressing CG32479 RNAi (positively marked by GFP), as demonstrated by immunostaining with antibodies specific for the NECD (arrows; F) and NICD (arrows; H), respectively. All phenotypes are fully penetrant (n > 20 discs).