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. 2012 Dec 6;7(12):e51200. doi: 10.1371/journal.pone.0051200

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© 2012 Xu et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Crystal structure of βB2-crystallin (PDB ID: 2BB2). The four subunits are labeled in cyan, green, orange and magenta, respectively. Leu15 at the N-terminus (red) and Trp195 at C-terminus (blue) are highlighted by the space-filling model to show the role of N-terminus in tetramerization of βB2-crystallin. (B) Sequence alignment of the N- and C-termini of β/γ-crystallins. The sequence alignment was performed using the online software MAFFT (http://www.ebi.ac.uk/Tools/msa/mafft/). The sequences used for alignment are: βB1-crystallin (BB1, P53674), βB2-crystallin (BB2, P43320), βB3-crystallin (BB3, P26998), βA3/A1-crystallin (BA3/BA1, P05813), βA2-crystallin (BA2, P53672), βA4-crystallin (BA4, P53673), γA-crystallin (GA, P11844), γB-crystallin (GB, P07316), γC-crystallin (GC, P07315), γD-crystallin (GD, P07320), γN-crystallin (GN, Q8WXF5) and γS-crystallin (GS, P22914).