Figure 7. TPGs with type 2 domains (not known to be involved in DNA-binding, protein-interaction, kinase or histone modification) play a role in boosting transcription and mRNA stability of fusion gene.

Comparison of TPGs with type 1 domains (grey boxes) and type 2 domains (white boxes). A: Transcription increase afforded by 5′ TPGs, calculated as ((Pol2 occupancy of 5′TPG promoter)−(Pol2 occupancy of 3′TPG promoter)). B: Decrease of 3′-UTR length afforded by 3′ TPGs, calculated as log2((3′-UTR length of 5′ TPG)/(3′-UTR length of 3′ TPG)). *, **: P<0.05, 0.01; two-tailed T-test.