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. 2012 Dec 6;8(12):e1003113. doi: 10.1371/journal.pgen.1003113

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© 2012 Lodder et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Congenic mice carrying the AKR/J green haplotype in a DBA/2J genetic background display the green haplotype PR interval duration. Overexpression of tagged hTNNI3k in a DBA/2J background significantly prolongs the PR interval. Colors show the haplotype of each strain at the Tnni3k locus, error bars indicate standard deviations. (B–D) Examples of ECG traces of DBA/2J (B), AKR.DBA.hrtfm2 congenic (C) and DBA/2J overexpressing hTNNI3K (D).