Table 2. Sensitivity and specificity of Wb123 IgG and IgG4 LIPS.
Compared to* | Normals | L. loa | O.volvulus | M. perstans | Other Helminths |
Sensitivity | |||||
IgG | 100 | 100 | 100 | 100 | 100 |
IgG4 | 98 | 98 | 98 | ND | 98 |
Specificity | |||||
IgG | 100 | 89 | 90 | 100 | 100 |
IgG4 | 100 | 99 | 100 | ND | 100 |
PPV ** | |||||
IgG | 100 | 87 | 90 | 100 | 100 |
IgG4 | 100 | 98 | 100 | ND | 100 |
NPV *** | |||||
IgG | 100 | 100 | 100 | 100 | 100 |
IgG4 | 96 | 99 | 98 | ND | 95 |
Calculations (Sensitivity, Specificity, PPV, NPV) are shown when the positive was defined as sera from proven Wuchereria bancrofti infection and the negative was defined as either normal (Normals), Loa loa-infected (L. loa). Onchocera volvulus-infected (O. volvulus), Mansonella perstans-infected (M. perstans) or infected with soil transmitted helminths (Other Helminths).
ND = not done.
Positive Predictive Value.
Negative Predictive Value.