Figure 1. Expression of ADRP and HSL is modulated by clofazimine in THP-1 cells infected with M. leprae.

THP-1 cells were cultured in six-well plates with culture medium containing either 8.0 µg/ml rifampicin, 5.0 µg/ml dapsone or 2.0 µg/ml clofazimine with M. leprae infection (MOI = 10). After incubating for 24 h, total RNA was purified and RT-PCR analysis of ADRP, HSL and β-actin was performed. Representative results from three independent experiments are shown.