Table 1.
Analysis of WTCCC Traits
| Trait or Study |
Total Heritability(SD) |
Chromosome 6 Heritability(SD) |
||||
|---|---|---|---|---|---|---|
| Standard | Weighted | Difference | Standard | Weighted | Difference | |
| Bipolar disease | 59 (6) | 69 (8) | +10 | 4 (2) | 5 (2) | 0 |
| Coronary artery disease | 39 (6) | 41 (8) | +3 | 2 (2) | 1 (2) | −1 |
| Crohn disease | 54 (6) | 58 (8) | +5 | 5 (2) | 6 (2) | +1 |
| Hypertension | 42 (6) | 52 (8) | +10 | 5 (2) | 8 (2) | +4 |
| Rheumatoid arthritis | 57 (6) | 52 (8) | −6 | 19 (2) | 17 (2) | −2 |
| Type 1 diabetes | 73 (6) | 74 (8) | 0 | 37 (2) | 35 (2) | −2 |
| Type 2 diabetes | 35 (6) | 44 (8) | +9 | 4 (2) | 5 (2) | +1 |
| Pseudo case-control study | 11 (10) | 7 (14) | −4 | 0 (2) | 1 (3) | +1 |
The variance explained by all SNPs and by just those on chromosome 6 with the use of both the standard and the weighted kinship matrix for the seven traits and the pseudo case-control study. The SD is the value given by the GCTA software.