Figure 3.

Sex-Specific Associations of Recombination Hotspots and De Novo CNVs with DNA Replication Timing

(A) Distribution of DNA replication timing for the entire genome (gray) and locations of hotspots of the sex-differentiated recombination rate, calculated by subtracting male recombination rates from female recombination rates.

(B) The average replication timing structure surrounding sex-differentiated recombination hotspots (as in Figure 1B).

(C) The replication timing structure surrounding male and female recombination hotspots separately, alongside control regions matched for GC content. When considering GC content, female recombination hotspots occur in later-replicating regions than expected for genomic regions with the same GC content (and not early replicating regions as suggested when ignoring GC content); male recombination hotspots occur in much later replicating regions than expected for regions with similar GC content (and hence do show an association with replication timing, in a negative direction, in contrast to the lack of association suggested when ignoring GC content).

(D) Large-scale correlation between male and female recombination and DNA replication timing.