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. 2012 Dec 7;91(6):977–986. doi: 10.1016/j.ajhg.2012.09.017

Figure 2.

Figure 2

Power Comparison of the Four Combination Procedures on the Burden Test and the C-alpha Test at the p Value Cutoff of 0.001

We compared the power of different combination procedures for different gene sizes as the number of risk-associated variants in each simulated gene increased from 0 to 10. The MAFs of the variants in the simulation range from 0.1% to 10%.