Table 1.

Power Comparison of the Four Combination Procedures at Different p Value Cutoffs

p Value Cutoff	Linear Combination	EC	Tippett’s Method	Fisher’s Method
0.001	0.186	0.266	0.191	0.169
0.005	0.270	0.381	0.286	0.252
0.010	0.326	0.450	0.349	0.306
0.050	0.496	0.636	0.538	0.484

The results are based on a simulation with genotype data from 60 CEU samples from the 1000 Genomes Project and simulated continuous phenotypes. The following abbreviation is used: EC, exponential combination.