Table 1.
Changes in plasma BuChE activity from baseline in pesticide handlers after stratification by PON1Q192R genotype and plasma PON1 activity
| Q192R Genotype | PON1 activity |
||
|---|---|---|---|
| High | Moderate | Low | |
| RR | +0.53% | -0.11% | -8.22%* |
| QR | -2.06% | -6.17%* | -7.58%* |
| -9.47%* | -7.23%* | -12.15%* | |
PON1 activity was determined as arylesterase activity: high (>145 U/mL); moderate (124-145 U/mL); low (<124 U/mL).
*
Significantly different from reference group (RR high), p<0.05 or more. Total n was 163; n in individual groups ranged from 7 to 29. Adapted from Hoffman et al. (2009).