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. 2012 Oct 25;107(12):1997–2004. doi: 10.1038/bjc.2012.477

Figure 1.

Figure 1

Fluorescence in situ hybridisation (FISH) for KRAS copy numbers showing no KRAS amplification with CEP12 (green)/KRAS probe (red) ratio 2:2 (A); KRAS gain with KRAS/CEP12 gene probe ratio 2:3 (B); KRAS amplification with KRAS/CEP12 gene probe ratio 2:4 (C); KRAS polysomy with KRAS/CEP12 ratio 4:6 (D) and impact of copy numbers on disease-specific survival in endometrial carcinoma (E). Survival curves are estimated by the Kaplan–Meier method with numbers of cases (events) given for cases with amplification/gain compared with unamplified cases. Proportion of cases with KRAS gene amplification/gain increased significantly from primary (13 of 414) to metastatic (11 of 61) lesions (P<0.001, FE test) (F).