Table 3. Toxicity of the FOLFOXIRI/erbitux combination in all patients and all cycles.
Grade 1 | Grade 2 | Grade 3 | Grade 4 | |||||
---|---|---|---|---|---|---|---|---|
No. of patients | % | No. of patients | % | No. of patients | % | No. of patients | % | |
Haematologic toxicity | ||||||||
Neutropenia | 3 | 10.0 | 5 | 16.7 | 6 | 20.0 | 1 | 3.3 |
Anaemia | 13 | 43.3 | 10 | 33.3 | 1 | 3.3 | — | — |
Thrombocytopenia | 7 | 23.3 | — | — | — | — | 2 | 6.7 |
Febrile neutropenia | — | — | 1 | 3.3 | — | — | 1 | 3.3 |
Non-haematologic toxicity | ||||||||
Nausea | 6 | 20.0 | 3 | 10.0 | 1 | 3.3 | — | — |
Vomiting | 3 | 10.0 | 3 | 10.0 | 4 | 13.3 | — | — |
Diarrhoea | 6 | 20.0 | 5 | 16.7 | 13 | 43.3 | 3 | 10.0 |
Stomatitis | 5 | 16.7 | 5 | 16.7 | 3 | 10.0 | — | — |
Constipation | 3 | 10.0 | — | — | — | — | — | — |
Neurotoxicity | 7 | 23.3 | 2 | 6.7 | — | — | — | — |
Allergy | 5 | 16.7 | 4 | 13.3 | — | — | — | — |
Asthenia | 8 | 26.7 | 6 | 20.0 | — | — | — | — |
Hand/Foot | 2 | 6.7 | 3 | 10.0 | 1 | 3.3 | — | — |
Rush | 6 | 20.0 | 4 | 13.3 | 1 | 3.3 | — | — |