Table 3.
Atherogenic peptides recognized by T-cells from early atherosclerotic lesions (EL) and from advanced late atherosclerotic lesions (LL).
| Number | Sequence | Location | Frequency |
|---|---|---|---|
| Atherogenic peptides from early atherosclerotic lesions | |||
| 50 | LSEKKISSIQSIVPA | 246–260 | 2/7 |
| 54 | AHRKPLVIIAEDVDG | 266–280 | 3/7 |
| 57 | EALSTLVLNRLKVGL | 281–295 | 3/7 |
| 66 | GEEGLTLNLEDVQPH | 326–340 | 3/7 |
| 84 | EKKDRVTDALNATRA | 416–430 | 3/7 |
| 85 | VTDALNATRAAVEEG | 421–435 | 2/7 |
| 88 | IVLGGGCALLRCIPA | 436–450 | 2/7 |
| 111 | KEEKDPGMGAMGGMG | 551–565 | 5/7 |
| Atherogenic peptides from late atherosclerotic lesions | |||
| 84 | EKKDRVTDALNATRA | 416–430 | 4/8 |
| 85 | VTDALNATRAAVEEG | 421–435 | 6/8 |
| 95 | TLKIPAMTIAKNAGV | 471–485 | 6/8 |
| 96 | AMTIAKNAGVEGSLI | 476–490 | 4/8 |
Eight common HSP60 peptides induced a proliferative response in early atherosclerotic lesion (EL) and four in late atherosclerotic lesions (LL). Overlapping amino acids are represented in bold.