FIGURE 2.

Crystal structure of TAT. A, ribbon representation of the TAT crystal structure bound to Ac-CoA; the latter is shown as a stick model. Colored dots represent regions of the polypeptide chain that are disordered in the crystal. B, TAT is a monomer in solution. Sedimentation coefficient distributions c(s) at 20 (blue) and 40 μm (cyan) are shown. C, conserved C-terminal phenylalanine-rich motif (circled in A, upper right). D, conserved hydrophobic network at the N terminus (circled in A, center).