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. 2012 Oct 11;287(50):41774–41786. doi: 10.1074/jbc.M112.407957

FIGURE 1.

FIGURE 1.

Human APOE genotype-specific delay of Aβ accumulation in 5xFAD mice: EFAD transgenic mice. A, representative images of sagittal brain sections of 2-, 4-, and 6-month-old 5xFAD and EFAD mice immunostained for Aβ (red) and NeuN (green), ×20 magnification (scale bar = 500 μm). B, total Aβ42 levels in the hippocampus of 6-month-old 5xFAD and EFAD mice measured by ELISA. Data are expressed as mean ± S.E. and were analyzed by one-way ANOVA followed by Tukey's multiple comparison post hoc analysis. *, p < 0.05 versus m-apoE; #, p < 0.05 versus apoE2 and apoE3.