SMEI-associated mutations exhibit reduced whole-cell current.
A, representative whole-cell current from cells stably expressing WT-NaV1.1 (top), R1648C (middle), or G1674R (bottom). B, current-voltage relationship of WT (filled circles), R1648C (open circles), and G1674R (filled triangles). All data are expressed as mean ± S.E. for 6–10 replicates. pF, picofarads.