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. 2012 Oct 19;287(50):42001–42008. doi: 10.1074/jbc.M112.421883

FIGURE 6.

FIGURE 6.

Lamotrigine rescues NaV1.1 channel function. A–C, representative whole-cell currents recorded from cells stably expressing WT-NaV1.1 (A), R1648C (B), or G1674R (C) grown in the presence of 0.1% DMSO (left) or 50 μm lamotrigine (middle). The right panel represents the average current voltage relationship of cells grown in the presence of either 0.1% DMSO (filled circles) or 50 μm lamotrigine (open circles). Data are expressed as mean ± S.E. for 10–12 replicates. An asterisk indicates p < 0.05 when compared with DMSO-treated cells. pF, picofarads.