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. 2012 Oct 19;287(50):42165–42179. doi: 10.1074/jbc.M112.377374

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — Effect of intragastric alcohol feeding on expression of PGC-1α and PGC-1α-regulated genes in the liver. A, intragastric alcohol feeding enhances PGC-1α expression in the liver. Solid bars, control (Cont); empty bars, alcohol treatment (Alc). B, intragastric alcohol feeding increases expression of PGC-1α-regulated genes TFAM, MCAD, and cytochrome c. PGC-1α levels in liver homogenate and TFAM, MCAD, and cytochrome c levels in isolated liver mitochondria were assessed by immunoblotting. Densitometry was performed using ImageJ. Actin was used as loading control in liver homogenate, and complex III was used as the loading control in isolated liver mitochondria. C, Mitochondrial respiration utilizing octanoate, a medium chain fatty acid, is enhanced in isolated liver mitochondria intragastric alcohol-fed mice. State III respiration was measured using octanoate (200 μm) plus ADP (250 μm) with an oxygen electrode. n = 4–6 mice/group. Results are mean ± S.D. (error bars); *, p < 0.05 versus control.