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PgDps is critical for P. gingivalis to grow under heme-replete conditions. A, gene map of wild-type strain W83, dps deletion mutant (Δdps), and complemented mutant (dps+) showing the position of the erythromycin resistance cassette (ermF/AM) and tetracycline resistance cassette (tetQ), respectively. B, growth of P. gingivalis wild-type W83 (●), Δdps mutant (■), and dps+ mutant (▴) in iron-depleted medium supplemented with 0.5 μm heme or 5 μm heme.
