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. 2012 Oct 2;287(50):42278–42287. doi: 10.1074/jbc.M112.418640

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© 2012 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — PIP₂ modulates gating of Kir channels by altering interactions between the CD loop, N terminus, and the αG helix of the GH loop. Shown is the effect of PIP₂ on averaged hydrophobic (Hp) interactions between Arg-219-Asp-61 (A) and salt bridge (SB) (B) interactions between His-221-Gln-51, Glu-292-Arg-44, and Glu-294-Arg-44 in the Kir2.2 WT. C, effect of PIP₂ on averaged hydrophobic interactions between Arg-219-Asp-61 (C) and salt bridge (D) interactions between His-221-Gln-51, Glu-292-Arg-44, and Glu-294-Arg-44 in Kir2.2 V224L.