Table 1.
Inhibitory Functions of anti-HIV Antibodies
| Target | Site of Antibody Block* | Recent References (Human Studies) |
|---|---|---|
| Virions ( Cell Free) |
Mucus Inhibition | [38] |
| Virion Aggregation | [39] | |
| Complement mediated Virolysis | [40,41] | |
| Virus Capture | [42,43] | |
| IgA Mediated Neutralization | [44,45] | |
| Traditional Virus Neutralization | [36,37,46,47] | |
| Infected Cells (Cell Associated Virus) |
Inhibition of Transcytosis | [8,48,49] |
| Intraepithelial Neutralization | [50] | |
| Fcγ-receptor (FcγR)- mediated: | [51] | |
| ADCC | [4,52] | |
| ADCVI | [53] | |
| Macrophage Neutralization | [37,54] | |
| Trigger of Innate Immunity | Release of β-chemokines | [10,11] |
*
Note: Some of the assays may inherently measure multiple steps of antibody blocking.