FIGURE 9.

Effect of varying MB dose on the efficiency of in vivo UMGD using cationic or neutral MBs. In vivo gene transfer increased with increasing MB dose for both cationic and neutral MBs with a plateau at 1x10⁸ MBs. Advantages in UMGD efficiency in using cationic over neutral MBs (C:N) was highest at the lowest MB dose. Bars are means of the maximum radiance at individual peak time points ± standard deviations (in photons/sec/cm²/sr, n=6 per group). * P < 0.05 comparing cationic and neutral MB groups.