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Schematic model of TWEAK-Fn14 signaling via Cdc42 and Rac1 to drive glioma migration/invasion. We propose that TWEAK engagement of the Fn14 receptor results in the activation of Cdc42 by the Ect2 GEF. Ect2-Cdc42 signaling results in the activation of Rac1 by the Trio GEF to drive glioma cell migration and invasion. PM, plasma membrane.
