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Peptide bicycles based on HT1. A) Chemical structures of BC1-4. Side-chains shown in red are implicated in direct SH2 domain binding in the known structure-activity relationships of G1. Purple and green side-chains comprise staples in positions modelled to be in close proximity, as shown in Fig. 2. B) Competition assay data for G1, HT1, and BC1-4. IC50 values reflect the curve fits shown.
