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EpoB ED50 values for S. cerevisiae strains with modified β-tubulin.
| Tubulin form | ED50, nM | Relative cytotoxicity, ED50(YYYYY)/ED50 |
|---|---|---|
| Tub2-BBBBB | 21 ± 3 | 125 |
| Tub2-BBBBY | 38 ± 8 | 69 |
| Tub2-BBYBB | 46 ± 6 | 57 |
| Tub2-BYBBB | 50 ± 7 | 53 |
| Tub2-BBBYB | 276 ± 50 | 10 |
| Tub2-YBBBB | 277 ± 28 | 10 |
| Tub2-YYYYY | 2,633 ± 362 | 1 |
The cytotoxicity of epothilone B for the different yeast strains was determined as described in the methods. Each ED50 reflects the average (±SEM) of three to five experiments.
