Table 2.
The EC50 and Emax values of CP55940, 11 and 12 for stimulation of [35S]GTPγS binding on hCB2-CHO cell membranes.
| Compound | Emax | EC50 | n |
|---|---|---|---|
| CP55940 | 84.7% (78.3 and 91.1%) | 1.8 nM (0.9 and 3.3 nM) | 4 |
| 11 | −52% (−57.2 and −46.4%) | 29.3 nM (16.5 and 52.2 nM) | 8 |
| 12 | −46.6% (−52.5 and −40.6%) | 57.6 nM (33.2 and 102.8 nM) | 8 |
The 95% confidence limits (CLs) are shown in brackets. n represents the number of data values.