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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Sep 7;51(40):10185–10189. doi: 10.1002/anie.201205601

Scheme 2.

Scheme 2

Reagents and conditions: a) (1) AgOTf, p-TolSCl, MS 4Å, −78°C, then 19, TTBP, −78°C–0°C; (2) Tf2O, THF, H2O; b) AgOTf, p-TolSCl, MS 4Å, −78°C, then 5, TTBP, −78°C–0°C; c) (1) AcOH, NH2NH2, DCM/MeOH; (2) 22, AgOTf, p-TolSCl, MS 4Å, TTBP, −78°C–0°C; d) AgOTf, p-TolSCl, MS 4Å, −78°C, then 23, TTBP, −78°C–0°C; e) AgOTf, p-TolSCl, MS 4Å, −78°C, then 5, TTBP, −78°C–0°C; f) AcOH, NH2NH2, DCM/MeOH.