Skip to main content
. Author manuscript; available in PMC: 2013 May 21.
Published in final edited form as: Angew Chem Int Ed Engl. 2012 Apr 5;51(21):5226–5229. doi: 10.1002/anie.201109258

Scheme 1.

Scheme 1

Reaction conditions for the synthesis of stilbene derivatives: (a) Styrene, Pd(OAc)2, CH3CN, DIPEA, 80 °C, 76%; (b) SnCl2·2H2O, EtOAc, 80 °C; (c) CNBr, MeOH:H2O 1:1, 50 °C, 91% (over two steps); (d) Imidazo[1,2-a]pyrimidine hydrobromide, Pd(OAc)2, PPh3, Cs2CO3, 1,4-dioxane, 100 °C, 82%; (e) 20% N2H4/EtOH, 105 °C, 84%; (f) Styrene, Pd(OAc)2, P(o-tolyl)3, NEt3, 100 °C, 73-76%. DIPEA = N,N-diisopropylethylamine.